The use of placebo as a control condition in clinical trials of major depressive disorder and anxiety disorders continues to be an area of ethical concern. Typically, opponents of placebo controls argue that they violate the beneficent-based, “best proven diagnostic and therapeutic method” that the original Helsinki Declaration of 1964 famously asserted participants are owed. A more consequentialist, oppositional argument is that participants receiving placebo might suffer enormously by being deprived of their usual medication(s). Nevertheless, recent findings of potential for (...) suicidality in young people treated with antidepressants, along with meta-analyses suggesting that antidepressants add no significant clinical benefit over placebos, warrant a re-evaluation of the arguments against placebo. Furthermore, the nature of placebo treatment in short-term clinical trials is often not well understood, and lack of understanding can foster opposition to it. This paper will show how scientific justifications for placebo use are morally relevant. The fundamental ethical importance of placebo controls is discussed in relation to several aspects of clinical trials, including detection of adverse events, accurate assessment of clinical benefit, advancing understanding of the heterogeneity of depression and anxiety disorders and respecting informed consent requirements. Prohibiting the use of placebo controls is morally concerning in that such prohibitions allow for the possibility of serious adverse public health consequences. Moral worries that research participants receiving placebo are being unduly jeopardised will be shown to be exaggerated, especially in relation to the net benefits for end-users to be gained from the quality of data resulting from using placebo controls. (shrink)

The late John Burrow, one of the most stimulating promoters of the distinctively interdisciplinary enterprise that is Intellectual History, was a vital member of what has become known as the ‘Sussex School’. In exploring the resonances of his singular and richly idiosyncratic contribution, this article places his unique historical sensibility within a series of interpretative contexts, demonstrating the vitality of writings that will continue to inspire and inform scholarship in the field for decades to come. ☆ The Sussex Centre for (...) Intellectual History Lecture delivered at the University of Sussex on 21st October, 2010. I am deeply indebted to Noël Sugimura for reading and commenting on an earlier version of the present essay with her customary sense and sensibility. (shrink)

The study of historiography is undergoing a revolution akin to that which took place in the history of political thought in the 1960s, and the work of J.G.A. Pocock is central to both. Pocock's continuing exploration, in Barbarism and Religion (1999-), of the intellectual contexts of Gibbon's History of the Decline and Fall of the Roman Empire, is central to this enterprise, and this essay situates the origins of his own work within a pre-‘Cambridge School’ Cambridge and its experience of (...) what might be called the Butterfieldian moment. That was marked by a desire to treat religion seriously as a driving force in history; and the same concern is applied here to further understanding an eighteenth-century controversy in which history and religion were dramatically involved, and which profoundly affected Gibbon's own historical and religious views. The work of Conyers Middleton and John Jortin is critically examined from this perspective. These preludes to Gibbon lead to a series of postludes examining the particular contexts in which Victorian and twentieth-century historians and writers, from Henry Hart Milman to Evelyn Waugh, variously appreciated and interpreted Gibbon. The whole is to be seen as a reflexive engagement with Pocock's vitally illuminating studies in eighteenth-century historiography. ☆ A slightly revised version of a lecture given at the University of Sussex on 22nd May 2008, on the occasion of a colloquium devoted to J.G.A. Pocock's Barbarism and Religion. It had originally acted as a prelude to a lecture by Pocock on the same occasion, subsequently published as ‘Gibbon and the invention of Gibbon: chapters 15 and 16 reconsidered’, History of European Ideas 35 (2009), 209–16. In this sense, therefore, the present essay has become a postlude. I am deeply grateful to Noël Sugimura for generously reading and commenting on the rescoring of a lecture into an essay. (shrink)

The dynamics of single populations up to ecosystems, are often described by one or a set of non-linear ordinary differential equations. In this paper we review the use of bifurcation theory to analyse these non-linear dynamical systems. Bifurcation analysis gives regimes in the parameter space with quantitatively different asymptotic dynamic behaviour of the system. In small-scale systems the underlying models for the populations and their interaction are simple Lotka-Volterra models or more elaborated models with more biological detail. The latter ones (...) are more difficult to analyse, especially when the number of populations is large. Therefore for large-scale systems the Lotka-Volterra equations are still popular despite the limited realism. Various approaches are discussed in which the different time-scale of ecological and evolutionary biological processes are considered together. (shrink)

This short and highly compact book derives from Paul Ricoeur’s lectures at Texas Christian University in fall 1973. After the expansiveness of earlier works on evil, Freud, and metaphor, this book moves to consolidate and sum up this previous work, and to chart a certain shift in Ricoeur’s standpoint that has occurred within it.

This provocative but persuasive book is essentially a radical attack upon the Humean conception of causality and the presentation and defense of a counter-theory, closer to everyday experience and pre-Humean traditional views. As formulated by empiricist philosophers, the Humean approach depends on two basic postulates. The philosophical analysis of any non-empirical concept must be a formal explication; any residue elements have to be accounted for in terms of their psychological origins. The world as experienced can be conceived adequately as a (...) logically independent system of things or flux of events, without the unwarranted assumption that individuals persist diachronically. As the grounds for undermining these assumptions, the authors develop a conception of causes as "powerful particulars," i.e., things which have both a nature and powers. So long as the nature remains unchanged the agent in question will continue to behave in this fashion with a natural necessity, stemming from the individual’s nature and specific powers. The opening chapter discusses the problem of conceptual and natural necessity—as distinct from logical necessity which alone is allowed by the Humean empiricists. Natural necessity is the mark of the relationship between real causes and their respective effects, whereas conceptual necessity characterizes the way our statements about such are themselves related. Later the irreducibility of natural necessity is emphasized and its differences from logical entailment spelled out. Chapter two takes up the subject of the "regularity theory and its allies." Characteristic of such are two claims: the empirical content of a causal-relationship statement is exhausted by the actual or hypothetical regularity between independent entities, and the necessity ordinarily attributed to causal production is an illusion, to be accounted for in various ways. Subsequent chapters are devoted to assaulting the pillars of the Humean notion either directly or indirectly through an illuminating and attractive account of their own theory of nature, causal powers, and natural necessity. The final chapter, entitled "Fields of Potential," indulges in speculation about the nature of ultimate entities on the basis of an extended generalization of the notion of the powerful individual, and concludes with a brief account of the historical antecedents of Faraday’s modern field theory and the metaphysical implications of a generalized field theory.—A.B.W. (shrink)